Redox Signaling and the Cardiovascular and Skeletal Muscle System

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Redox Signaling and the Cardiovascular and Skeletal Muscle System

1Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA 2Cardiac Aging & Redox Signaling Laboratory, Division of Molecular & Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA 3Division of Cardiovascular Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, U...

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Redox signaling in skeletal muscle: role of aging and exercise.

Skeletal muscle contraction is associated with the production of ROS due to altered O2 distribution and flux in the cell. Despite a highly efficient antioxidant defense, a small surplus of ROS, such as hydrogen peroxide and nitric oxide, may serve as signaling molecules to stimulate cellular adaptation to reach new homeostasis largely due to the activation of redox-sensitive signaling pathways....

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The rainbow trout skeletal muscle -adrenergic system: characterization and signaling

Lortie, Michel B., and Thomas W. Moon. The rainbow trout skeletal muscle -adrenergic system: characterization and signaling. Am J Physiol Regul Integr Comp Physiol 284: R689–R697, 2003. First published November 21, 2002; 10.1152/ajpregu.00512.2002.—The presence and functionality of -adrenoceptors ( -ARs) were examined in red (RM) and white muscle (WM) membranes isolated from the rainbow trout O...

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Role of Redox Signaling and Inflammation in Skeletal Muscle Adaptations to Training

The inflammatory response to exercise-induced muscle damage has been extensively described. Exercise has important modulatory effects on immune function. These effects are mediated by diverse factors including pro-inflammatory cytokines, classical stress hormones, and hemodynamic effects leading to cell redistribution. As has been reported regarding oxidative stress, inflammation can have both ...

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Redox Characterization of Functioning Skeletal Muscle

Skeletal muscle physiology is influenced by the presence of chemically reactive molecules such as reactive oxygen species (ROS). These molecules regulate multiple redox-sensitive signaling pathways that play a critical role in cellular processes including gene expression and protein modification. While ROS have gained much attention for their harmful effects in muscle fatigue and dysfunction, r...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2015

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2015/849095